Stage I Melanoma

Stage I melanoma is defined as a melanoma that is up to 2 mm thick. A Stage I melanoma may or may not have ulceration. There is no evidence the cancer has spread to lymph nodes or distant sites (metastasis). There are two subclasses of Stage I melanoma: 1A, 1B.
Stage I Melanomas Are Defined by 3 Primary Characteristics:
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Tumor thickness (Breslow Depth): how deeply the tumor has penetrated the skin. Thickness is measured in millimeters (mm). For example:
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1 mm = .04 inch, or less than 1/16 inch (about equal to the edge of a penny)
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2 mm = between 1/16 and 1/8 inch (about equal to the edge of a nickel)
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4 mm = between 1/8 and 1/4 inch (about equal to the edges of two nickels)
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Ulceration: when the epidermis (or top layer of skin) that covers a portion of the primary melanoma is not intact. Ulceration can only be seen under a microscope, not by the naked eye.
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Mitotic Count (Rate): is a secondary characteristic that describes how quickly the tumor cells are dividing. Mitotic count is calculated by a pathologist who counts the average number of activily dividing cells in the biopsy sample.
Note: Clark Level has been replaced as a criteria by the AJCC in 2010.
There Are 2 Subclasses of Stage I Melanoma

Risk: Patients with Stage I Melanoma are considered low risk for local recurrence or for regional and distant metastases. Keep in mind that the statistics shown for survival are averages; everyone's cancer and survival rate is based on many factors and determined on an individual basis.
For more information, see Stage I Follow-up.
FAST FACTS
Stage I Melanoma:
Localized Tumor
Subclasses 1A, 1B
Localized tumor
Hasn't spread to lymph nodes or distant sites
Risk: You're considered to be at low risk for recurrence and metastasis when you have Stage I melanoma.
The following factors detemine the stage of melanoma:
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Tumor thickness:
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Breslow Scale
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Whether the tumor is with or without ulceration
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Mitotic Count (Rate)
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Whether the metastasis is Microscopic (tiny tumors not visible to naked eye) or macroscopic (tumors large enough to be visible or that can be felt)
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Site of distant metastasis: skin vs other areas
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Level of LDH (serum lactate dehydrogenase)

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