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General Cancer Research

2014

Imaging: Cancer Caught in the Act

Increasingly, cancer researchers are embracing the chance to spy on individual tumour cells in their native environment. Tracking cancer in live animals over time - an approach called intravital imaging.

May 7, 2014

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Serious Side Effect: Several FDA-Approved Anti-Cancer Drugs Induce Stem Cell Tumors

In a surprise finding, researchers discovered that several chemotherapeutics that do stop fast growing tumors have the opposite effect on stem cells in the same animal, causing them to divide too rapidly.

March 10, 2014

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New Therapies Raise Hope for a Breakthrough in Tackling Cancer

Although a range of new cancer treatments, such as targeted chemotherapy for breast cancer and cell-signaling inhibitors for leukemia, have shown positive effects over the past two decades, the checkpoint inhibitors seem to be providing uniquely long-term benefits.

February 18, 2014
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2013

Height Linked To Women's Cancer Risk? New Study Suggests Yes

Height does matter - at least it may when it comes to cancer risk.

July 25, 2013

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2012

Cancer Costs Billions Yearly in U.S. Worker Productivity: Study

The cost of lost productivity among U.S. workers with cancer is equal to 20 percent of the nation's health care spending, according to a new study.

December 17, 2012

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Yale Cancer Center Finds Drug Combinations to Fight Skin Cancers More Effectively

Yale Cancer Center researchers say they've identified a series of drug combinations that may lead to better, longer-lasting treatments for a host of skin cancers.

December 13, 2012

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Cancer Group Calls for FDA Crackdown on Tanning Beds

The American Cancer Society is urging federal officials to "impose greater control" over the manufacture and distribution of tanning beds, citing an elevated risk of cancer from their use.

December 13, 2012

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Cancer Treatment: 'Smart Bomb' Developed

Scientists have successfully tested a capillary "smart bomb" that simultaneously attacks cancer and boosts the immune system.

July 15, 2012

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Ineffectiveness of Cancer Drugs May Be due to Healthy Surrounding Cells

Researchers and doctors have consistently been baffled by cancer cases in which treatments conducted kill the cancer cells in the laboratory, but provide only partial results in patients, with the cancer returning in as little as a few months. The answers do not lie in the cancer cells themselves, but in the healthy cells in the environment next to them.

July 5, 2012

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2011

Researchers Study How Patterns, Timing of Sunlight Exposure Contribute to Skin Cancers

Researchers at Moffitt Cancer Center, the University of South Florida and the International Agency for Research on Cancer in France have studied the patterns and timing of sunlight exposure and how each is related to two nonmelanoma skin cancers - basal cell carcinoma and squamous cell carcinoma

October 23, 2012

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Blood Pressure Drugs May Lengthen Lives of Melanoma Patients

Beta-blocker drugs, commonly used to treat high blood pressure, may also play a major role in slowing the progression of certain serious cancers, based on a new study.

September 21, 2011

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BAP1 Mutation Linked To Higher Risk of Mesothelioma and Melanoma of the Eye

Researchers have discovered that individuals carrying a mutation in the BAP1 gene are at greater risk of developing mesothelioma and uveal melanoma.

September 6, 2011

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Skin Cancer Vaccine May Be Available Within 1-Year

An Australian scientist is on the verge of creating the world's first skin cancer vaccine.

August 1, 2011

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Researchers Improve Method For Finding Genetic Mistakes That Fuel Cancer

A dramatically better computer tool for finding the genetic missteps that fuel cancer has

been developed by St. Jude Children's Research Hospital - Washington University

Pediatric Cancer Genome Project Investigators.

June 10, 2011

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Evidence Backs Melanoma-Parkinson's Association

People with Parkinson's disease are twice as likely as those without the neurological disorder to get a diagnosis of the skin cancer melanoma, a new review of the evidence concludes.

June 6, 2011

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2010

Drug Shortages Roiling Oncology Practices, Impinging on Patient Care

An ongoing shortage of some crucial chemotherapy drugs is driving up the cost of the products and forcing oncologists to scramble for supplies or to find therapeutically equivalent alternatives, if there are any.

December 16, 2010

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Brief Decline In Quality Of Life Seen After Brain Radiotherapy

Adjuvant whole-brain radiotherapy following surgical or radiosurgical resection of brain metastases provided no survival benefit and modestly reduced health-related quality of life when compared with close MRI observation alone in a randomized study of 359 patients.

December 15, 2010

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Ultraviolet Light - Major Risk Factor In Skin Cancer

A team of researchers have reported sun's ultraviolet radiation plays a key role in proliferation and survival of skin cancer cells.

December 10, 2010

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Skin Formation Study Suggests Strategies To Fight Skin Cancer

In a study published in the journal Development Cell, researchers demonstrate that a pair of enzymes called HDACs are critical to the proper formation of mammalian skin.

December 8, 2010

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Cancer Risk From CT Scans May Be Lower Than Thought

Radiation-induced cancer is a big fear as the use of CT scans for all kinds of medical diagnoses increases.  Clearly, unnecessary radiation should be avoided.  But a new study suggests that the cancer risk may have been overestimated.

December 1, 2010

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Scientists Turn a New Leaf To Discover a Compound in Daffodils That Targets Brain Cancer

A new research study published in the November 2010 print issue of The FASEB Journal offers hope that a natural compound in daffodil bulbs, called narciclasine, may be a powerful therapeutic against biologically aggressive forms of human brain cancers.

November 1, 2010

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Update 2 - Delcath Cancer System Could Get OK Mid-2011--CFO 

Declath Systems Inc expects to finish an application for U.S. review of its cancer drug delivery system in the fourth quarter, which would put it on track for approval by mid-2011.

September 28, 2011

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Kansas Research Team Uses Particles to Battle Cancer

A team at Kansas State University is exploring the use of nano-particle induced hyperthermia to battle cancer cells in pre-clinical trials.

June 28, 2010

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bioMerieux and GlaxoSmithKlane Enter into Alliance to Develop Molecular Theranostic Test for Cancer Treatment Selection

The two companies signed an agreement to develop a novel molecular test for cancer to aid oncologists in choosing the appropriate treatment for metastatic melanoma.

May 11, 2010

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Shutting Out Soft Tissue Cancers in the Cold

"Cryotherapy, an interventional radiology treatment to freeze cancer tumors, may become the treatment of the future for cancer that has metastasized in soft tissues
(such as ovarian cancer) and in bone tumors."
March 16, 2010

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Gene Test Aid to Cancer Treatment

To predict how well chemotherapy will work. "Starting with 829 genes in breast cancer cells, the team [Cancer Research UK] whittled down the possibilities to six genes which had an impact on whether a drug worked. They then showed that these genes could be used to predict the effectiveness of a drug called paclitaxel in patients." To try out in other cancers.
March 1, 2010

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Cancer Detection Blood Test Hope

"Personalized blood tests which could track whether cancer treatment is working or if the disease has come back have been developed by US researchers."
February 19, 2010

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2009

New Stem Cell Lines Open to Research
From NIH.
December 2, 2009

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Experimental Cancer Vaccine Goes into Clinical Trials
"Cornell University researchers have produced the first batch of a cancer vaccine known as NY-ESO-1 recombinant protein that will be used in clinical trials for patients facing either ovarian cancer or melanoma.... [I]t has been the central focus of a global network of laboratory and clinical scientists...."
September 1, 2009 

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SNP Link to Several Cancers [but Protect Against Melanoma]
Iceland's K. Stefansson of deCODE and others of the international team "linked  common single nucleotide polymorphisms (SNPs) on chromosome 5 to five different types of cancer while at the same time conferring protection against melanoma."  TERT-CLPTM1L in the chromosome 5p15 region. In Nature Genetics.
January 28, 2009
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2008

In Long-Awaited Maps of Cancer, The Breakthrough Is the Problem
3 major studies.  “… [T]he picture is enormously complicated. For example, scientists had expected to identify certain key genes that were frequently mutated. They found the opposite: a large number of mutated genes, but each mutated in a smaller fraction of the tumors.”
September 5, 2008

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Gene Trawl Shows Curing Cancer Harder than Thought
“The findings suggest that popular new targeted therapies may not work broadly,  because they affect only one mutated gene, while cancer is caused by dozens. A better approach would be to find the pathways — networks of genes — that control a tumor's uncontrolled growth.”
September 4, 2008
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Genetic Mutations Linked to Deadly Cancers.  Findings of 3 Studies Focus on Brain and Pancreatic Tumors.
“The findings suggest that most solid tumors, particularly those of the brain and pancreas, won't respond to treatments that target a single gene.”
September 4, 2008
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Numerous Undiscovered Gene Alterations in Pancreatic and Brain Cancers Detected
“The best hope for new therapies may lie in the discovery of agents that target the physiologic effects of the altered pathways and processes, rather than their individual genetic components."
September 4, 2008
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Trouble at the Office.  Comprehensive Discussion of Issues Between Drug Companies and FDA on Clinical Trials and Criteria for Cancer Drugs 

Importance of “surrogate endpoints” as alternatives to overall survival data. Some history on the failure of the FDA to approve Genasense for melanoma and the new current trial.
September 12, 2008
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