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Stage II Melanoma

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Stage II Melanoma is defined by tumor thickness and ulceration. There is no evidence the cancer has spread to nearby lymph nodes or to distant sites (metastasis).

Stage II Melanomas are Defined by 2 Primary Characteristics: 

  • Tumor thickness (Breslow Depth): how deeply the tumor has penetrated the skin. Thickness is measured in millimeters (mm). For example:

     

    • 1 mm = .04 inch, or less than 1/16 inch (about equal to the edge of a penny)

    • 2 mm = between 1/16 and 1/8 inch (about equal to the edge of a nickel)

    • 4 mm = between 1/8 and 1/4 inch (about equal to the edges of two nickels)

     

  • Ulceration: when the epidermis (or top layer of skin) that covers a portion of the primary melanoma is not intact. Ulceration can only be seen under a microscope, not by the naked eye.

     

There Are 3 Subclasses of Stage II Melanoma:


Stage IIA (T2bN0M0 or T3aN0M0)

 

T2b:  tumor is 1.01 - 2.0 mm thick, with ulceration

T3a:  tumor is 2.01 - 4.0 mm thick, with no ulceration

N0: No spread to nearby lymph nodes

M0: No evidence of metastasis to distant sites

 

 

Stage IIB (T3N0M0 or T4aN0M0)

T3b: tumor is 2.01 - 4.0 mm thick, with ulceration

T4a: tumor is greater than 4.0 mm thick, with no ulceration

N0: No spread to nearby lymph nodes

M0: No evidence of metastasis to distant sites

 

 

 

Stage IIC (T4bN0M0)


T4b: tumor is greater than 4.0 mm thick, with ulceration

N0: No spread to nearby lymph nodes

M0: No evidence of metastasis to distant sites

 

 

 


 

Risk: With treatment, Stage II Melanoma is considered intermediate to high risk for local recurrence or distant metastasis. Keep in mind that the statistics shown for survival are only averages; everyone's cancer and survival rates is based on many factors and determined on an individual basis.

 

For more information on stage II follow-up.



FAST FACTS

Stage II Melanoma:
Localized tumor

Subclassses IIA, IIB, IIC

 

Differentiated by tumor thickness (Breslow depth)

 

It hasn't spread to nearby lymph nodes or distant sites

 

Risk is intermediate for occurring again in the same spot or spreading to distant sites

The following factors determine the stage of melanoma:

  • Tumor thickness

  • Whether the tumor is with or without ulceration

  • Mitotic Count (Rate)

  • Whether the metastasis is microscopic (tiny tumors not visible to naked eye) or macroscopic (tumors large enough to be visible or  that can be felt)

  • Site of distant metastasis: skin vs other areas

  • Level of LDH (serum lactate dehydrogenase