Blog

Eric D. Whitman, MD
Director médico, Atlantic Health System
Director de Atención al Cáncer, Centro de Melanoma del Atlántico

Question: Which clinical trials do you believe are particularly exciting?

Answer: In my opinion, the most exciting research happening in the melanoma world right now falls into two categories.

The first type of exciting research investigates the use of biomarkers to predict response to treatment. As it applies to melanoma, a “biomarker” is a blood, tissue or even stool test that assesses a patient’s ability to respond, or not, to therapy. Is your immune system ready to respond to the latest immunotherapy? Is there something about your melanoma tumor that predicts it will never respond to another therapy? Is your melanoma likely to come back or metastasize? Not only are these questions important clinically, they also can have a significant financial impact, given the high cost of so many tests and treatments today. These are all very important questions, and investigators are actively seeking ways to provide us with the answers.

El segundo tipo de investigación apasionante consiste en combinar la inmunoterapia aprobada, especialmente los inhibidores de puntos de control, con nuevos agentes que podrían preparar al sistema inmunitario para eliminar el cáncer. Estos nuevos fármacos no suelen tener prácticamente ningún efecto, bueno o malo, por sí mismos, pero podrían ayudar al sistema inmunitario a responder con mayor eficacia a la inmunoterapia estándar. Por ejemplo, muchos pacientes, por desgracia, no responden a los fármacos de inmunoterapia actuales. Sin embargo, si los tratáramos al mismo tiempo con un agente "cebador", ¿podrían responder aunque la terapia estándar haya fracasado previamente?

A pesar de lo mortal que puede ser el melanoma, no cabe duda de que estamos en medio de una transformación de una época en la que casi nada ayudaba, a una época con muchos tratamientos eficaces, a menudo con una toxicidad sorprendentemente baja. Será fascinante ver lo que nos deparan los próximos años.

Regístrese para asistir a nuestro Simposio de Pacientes que Viven con Melanoma en el Atlantic Melanoma Center el sábado 15 de septiembre y escuche la actualización del tratamiento del melanoma 2018 del Dr. Whitman. 

 

Jeffrey Farma, MD
Profesor Asociado, Departamento de Oncología Quirúrgica,
Centro Oncológico Fox Chase

Question: What particular clinical trial do you currently have open at your institution that you are excited about?

Answer: We have had increased interest in neoadjuvant treatment of melanoma. Neoadjuvant treatment is giving therapy like immunotherapy prior to surgical resection in hopes of improving response and survival in more locally advanced melanoma. We are opening our first neoadjuvant clinical trial here this month, called NeoDREAM- An Open-Label, Randomized, Controlled Multi-Center Study of the Efficacy of Darorum (LI9IL2 + L19TNF) Neoadjuvant Intratumoral Treatment Followed by Surgery versus Surgery Alone in Clinical Stage IIIB/C Melanoma Patients. In patients who present or have a recurrence with palpable lymph nodes, or in-transit nodules, the investigational group will have an injection into their lymph node or lesion for 4 weeks prior to surgery and then undergo resection. We will be able to evaluate the tumor for changes from the injections and determine if these patients have a different chance of recurrence and survival. I believe the neoadjuvant approach for select patients will be the future of how we treat some melanoma patients and am excited to have this novel trial opening at Fox Chase Cancer Center.

Inscríbase para asistir a nuestro Simposio de Pacientes que Viven con Melanoma en el Centro Oncológico Fox Chase el sábado 22 de septiembre y escuche la presentación del Dr. Farma sobre el tratamiento posquirúrgico.

 

Dra. Katy Tsai
Centro Oncológico Familiar Helen Diller de la UCSF

Question: What particular clinical trial do you currently have open at your institution that you are excited about?

Answer: In terms of currently open clinical trials at UCSF, I would say that I am excited about an agent called CMP-001 (A Multicenter, Two Part Open-Label, Phase 1b Clinical Study of CMP-001 Administered Either in Combination with Pembrolizumab or as Monotherapy in Subjects with Advanced Melanoma) sponsored by CheckMate Pharmaceuticals. There is a need for treatment options for patients who progress despite anti-PD-1 therapy, and this trial focuses on that population. This study drug, a TLR9 agonist, is thought to increase anti-tumor T cell activity by increasing the efficiency with which the immune system is able to recognize cancer cells, and earlier work suggests that this may be able to elicit tumor response in patients who either stopped responding to anti-PD-1, or perhaps never responded in the first place. This agent is also different in that it is injected directly into the tumor, and I am hopeful that toxicities will be less frequent and less severe than other drugs that are given systemically (injected into a vein, or taken by mouth).

Regístrese para asistir a nuestro Simposio de Pacientes que Viven con Melanoma en el Centro Oncológico Helen Diller de la UCSF el sábado 29 de septiembre y escuche la presentación del Dr. Tsai sobre Melanoma y Futura Fertilidad: ¿Qué sabemos?