I’ve Failed First-Line Therapy – Now What?

Published:  
10/07/2025
Image

A Free Educational Webinar for Melanoma Patients and Caregivers
Wednesday, October 16 | 7:00–7:30 PM ET

Facing melanoma can be overwhelming—especially when initial treatment doesn’t go as hoped. If you’ve recently learned that your first-line therapy has stopped working, or you’re supporting someone who has, you may be wondering what comes next.

Our upcoming live webinar, “I’ve Failed First-Line Therapy – Now What?”, is designed to help you understand your options, prepare for informed discussions with your care team, and explore the latest advancements in treatment and research.


About the Webinar

Host: Melissa Wilson, PA-C, MPAS, host of AIM’s From the Clinic the Living Room webinar series
Guest Speaker: Allison Betof, MD, PhD, Associate Professor of Medicine (Oncology), Stanford University School of Medicine

This 30-minute session will feature expert insight from two leaders in melanoma care who are dedicated to patient education and improving outcomes for individuals facing treatment-resistant or advanced disease.


What You’ll Learn

Understanding Treatment Failure

  • What it means when first-line therapy is no longer effective
  • Recognizing signs of disease progression
  • Distinguishing between treatment failure and side-effect intolerance

Navigating the Next Steps

  • When to initiate a conversation with your oncologist
  • How to bring up concerns and ask the right questions
  • The value of timely reassessment and seeking second opinions

Exploring New Treatment Options

  • Standard-of-care second-line and subsequent therapies
  • Advances in immunotherapy, targeted therapy, and combination approaches
  • When and how to consider clinical trial opportunities

The Role of Biomarkers and Genetic Testing

  • How molecular profiling can inform next-line therapy
  • Personalized approaches based on tumor characteristics

Managing Quality of Life

  • Strategies for addressing side effects and maintaining well-being
  • How supportive care teams—nursing, pharmacy, nutrition, and social work—can help coordinate care

Patient Advocacy and Communication

  • Questions to ask your provider
  • How to advocate for timely follow-up and individualized treatment planning

About Our Guest Expert: Allison Betof, MD, PhD

Allison Betof, MD, PhD, is an internationally recognized expert in cutaneous oncology and melanoma at Stanford University School of Medicine. She serves as the Director of the Melanoma Program, Director of Solid Tumor Cellular Therapy, and Mark & Mary Stevens Endowed Scholar in Melanoma.

Her laboratory research focuses on understanding resistance to immune checkpoint blockade and advancing cellular therapies for melanoma and other solid tumors. Dr. Betof leads clinical trials exploring novel therapies for immunotherapy-refractory melanoma and is a pioneer in the clinical use of tumor-infiltrating lymphocyte (TIL) therapy.


About the Host: Melissa Wilson, PA-C, MPAS

Melissa Wilson is a senior physician assistant and melanoma specialist at UPMC Hillman Cancer Center with nearly two decades of experience caring for melanoma patients and their families. She has worked alongside world-renowned melanoma expert Dr. John Kirkwood at the University of Pittsburgh Cancer Institute, contributing to research and clinical advancements that have shaped melanoma care nationwide.

Melissa is a passionate advocate for patient education and collaboration. She also serves as adjunct faculty at Chatham University, where she lectures on melanoma care and clinical practice.


Register to Attend

Join us on Wednesday, October 16, from 7:00 to 7:30 PM ET for this important and empowering discussion.
Participation is free, but registration is required.

Reserve your spot