No cancer, including melanoma, can ever be prevented with 100% certainty. Some risk factors for melanoma, such as skin type and family history, cannot be changed. Sometimes melanoma may develop despite your best efforts to prevent it.
The good news is that the risk factors for melanoma are well known. Since the primary risk factor for melanoma is exposure to ultraviolet (UV) radiation, learning how you can protect yourself from UV radiation can help you reduce your risk of melanoma.